The restorative effect of intramuscular injection of tetanus toxin C-fragment in hemiparkinsonian rats.
Identifieur interne : 000C54 ( Main/Exploration ); précédent : 000C53; suivant : 000C55The restorative effect of intramuscular injection of tetanus toxin C-fragment in hemiparkinsonian rats.
Auteurs : Alejandra Sánchez-González [Mexique] ; Liliana Mendieta [États-Unis] ; Victoria Palafox [Mexique] ; Anna Candalija [Espagne] ; Félix Luna [Mexique] ; José Aguilera [Espagne] ; Ilhuicamina Daniel Lim N [Mexique]Source :
- Neuroscience research [ 1872-8111 ] ; 2014.
Descripteurs français
- KwdFr :
- Activité motrice (), Agents adrénergiques (toxicité), Analyse de variance, Animaux, Curarisants (usage thérapeutique), Facteurs temps, Fragments peptidiques (usage thérapeutique), Injections musculaires, Latéralité fonctionnelle (), Maladie de Parkinson (physiopathologie), Maladie de Parkinson (traitement médicamenteux), Maladie de Parkinson (étiologie), Modèles animaux de maladie humaine, Numération cellulaire, Oxidopamine (toxicité), Rat Wistar, Rats, Toxine tétanique (usage thérapeutique), Tyrosine 3-monooxygenase (métabolisme).
- MESH :
- métabolisme : Tyrosine 3-monooxygenase.
- physiopathologie : Maladie de Parkinson.
- toxicité : Agents adrénergiques, Oxidopamine.
- traitement médicamenteux : Maladie de Parkinson.
- usage thérapeutique : Curarisants, Fragments peptidiques, Toxine tétanique.
- étiologie : Maladie de Parkinson.
- Activité motrice, Analyse de variance, Animaux, Facteurs temps, Injections musculaires, Latéralité fonctionnelle, Modèles animaux de maladie humaine, Numération cellulaire, Rat Wistar, Rats.
English descriptors
- KwdEn :
- Adrenergic Agents (toxicity), Analysis of Variance, Animals, Cell Count, Disease Models, Animal, Functional Laterality (drug effects), Injections, Intramuscular, Motor Activity (drug effects), Neuromuscular Blocking Agents (therapeutic use), Oxidopamine (toxicity), Parkinson Disease (drug therapy), Parkinson Disease (etiology), Parkinson Disease (physiopathology), Peptide Fragments (therapeutic use), Rats, Rats, Wistar, Tetanus Toxin (therapeutic use), Time Factors, Tyrosine 3-Monooxygenase (metabolism).
- MESH :
- chemical , metabolism : Tyrosine 3-Monooxygenase.
- chemical , therapeutic use : Neuromuscular Blocking Agents, Peptide Fragments, Tetanus Toxin.
- chemical , toxicity : Adrenergic Agents, Oxidopamine.
- drug effects : Functional Laterality, Motor Activity.
- drug therapy : Parkinson Disease.
- etiology : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Analysis of Variance, Animals, Cell Count, Disease Models, Animal, Injections, Intramuscular, Rats, Rats, Wistar, Time Factors.
Abstract
The C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) is a peptide that has a neuroprotective action against dopaminergic damage by MPP(+), both in vitro and in vivo. The trophic effects of Hc-TeTx have been related to its ability to activate the pathways of the tropomyosin receptor kinase, which are crucial for survival process. Our group had previously shown neuroprotective effect of intramuscular Hc-TeTx treatment on animals with a dopaminergic lesion; however, there is no evidence indicating its restorative effects on advanced dopaminergic neurodegeneration. The aim of our study was to examine the restorative effects of an intramuscular injection of the Hc-TeTx fragment on the nigrostriatal system of hemiparkinsonian rats. The animals were administered with a vehicle or Hc-TeTx (20μg/kg) in the gastrocnemius muscle for three consecutive days post-dopaminergic lesion, which was made using 6-hydroxydopamine. Post-Hc-TeTx treatment, the hemiparkinsonian rats showed constant motor asymmetry. Moreover, the ipsilateral striatum of the post-Hc-TeTx group had a lower number of argyrophilic structures and a major immunorreactivity to Tyrosine Hydroxylase in the striatum and the substantia nigra pars compacta compared to the 6-OHDA group. Our results show the restorative effect of the Hc-TeTx fragment during the dopaminergic neurodegeneration caused by 6-OHDA.
DOI: 10.1016/j.neures.2014.04.008
PubMed: 24815514
Affiliations:
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Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratorio de Neurofarmacología, Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Palafox, Victoria" sort="Palafox, Victoria" uniqKey="Palafox V" first="Victoria" last="Palafox">Victoria Palafox</name><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Neurofarmacología, Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Neurofarmacología, Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla</wicri:regionArea><wicri:noRegion>Puebla</wicri:noRegion></affiliation></author><author><name sortKey="Candalija, Anna" sort="Candalija, Anna" uniqKey="Candalija A" first="Anna" last="Candalija">Anna Candalija</name><affiliation wicri:level="4"><nlm:affiliation>Departament de Bioquímica i Biologia Molecular and Institut de Neurociències, Universitat Autònoma de Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament de Bioquímica i Biologia Molecular and Institut de Neurociències, Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Luna, Felix" sort="Luna, Felix" uniqKey="Luna F" first="Félix" last="Luna">Félix Luna</name><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Neurofarmacología, Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Neurofarmacología, Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla</wicri:regionArea><wicri:noRegion>Puebla</wicri:noRegion></affiliation></author><author><name sortKey="Aguilera, Jose" sort="Aguilera, Jose" uniqKey="Aguilera J" first="José" last="Aguilera">José Aguilera</name><affiliation wicri:level="4"><nlm:affiliation>Departament de Bioquímica i Biologia Molecular and Institut de Neurociències, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament de Bioquímica i Biologia Molecular and Institut de Neurociències, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Lim N, Ilhuicamina Daniel" sort="Lim N, Ilhuicamina Daniel" uniqKey="Lim N I" first="Ilhuicamina Daniel" last="Lim N">Ilhuicamina Daniel Lim N</name><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Neurofarmacología, Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico. Electronic address: ilhlimon@yahoo.com.mx.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Neurofarmacología, Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla</wicri:regionArea><wicri:noRegion>Puebla</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neuroscience research</title><idno type="eISSN">1872-8111</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenergic Agents (toxicity)</term><term>Analysis of Variance</term><term>Animals</term><term>Cell Count</term><term>Disease Models, Animal</term><term>Functional Laterality (drug effects)</term><term>Injections, Intramuscular</term><term>Motor Activity (drug effects)</term><term>Neuromuscular Blocking Agents (therapeutic use)</term><term>Oxidopamine (toxicity)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (physiopathology)</term><term>Peptide Fragments (therapeutic use)</term><term>Rats</term><term>Rats, Wistar</term><term>Tetanus Toxin (therapeutic use)</term><term>Time Factors</term><term>Tyrosine 3-Monooxygenase (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activité motrice ()</term><term>Agents adrénergiques (toxicité)</term><term>Analyse de variance</term><term>Animaux</term><term>Curarisants (usage thérapeutique)</term><term>Facteurs temps</term><term>Fragments peptidiques (usage thérapeutique)</term><term>Injections musculaires</term><term>Latéralité fonctionnelle ()</term><term>Maladie de Parkinson (physiopathologie)</term><term>Maladie de Parkinson (traitement médicamenteux)</term><term>Maladie de Parkinson (étiologie)</term><term>Modèles animaux de maladie humaine</term><term>Numération cellulaire</term><term>Oxidopamine (toxicité)</term><term>Rat Wistar</term><term>Rats</term><term>Toxine tétanique (usage thérapeutique)</term><term>Tyrosine 3-monooxygenase (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Neuromuscular Blocking Agents</term><term>Peptide Fragments</term><term>Tetanus Toxin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Adrenergic Agents</term><term>Oxidopamine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Functional Laterality</term><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Tyrosine 3-monooxygenase</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Maladie de Parkinson</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Agents adrénergiques</term><term>Oxidopamine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladie de Parkinson</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Curarisants</term><term>Fragments peptidiques</term><term>Toxine tétanique</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Maladie de Parkinson</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Cell Count</term><term>Disease Models, Animal</term><term>Injections, Intramuscular</term><term>Rats</term><term>Rats, Wistar</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activité motrice</term><term>Analyse de variance</term><term>Animaux</term><term>Facteurs temps</term><term>Injections musculaires</term><term>Latéralité fonctionnelle</term><term>Modèles animaux de maladie humaine</term><term>Numération cellulaire</term><term>Rat Wistar</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) is a peptide that has a neuroprotective action against dopaminergic damage by MPP(+), both in vitro and in vivo. The trophic effects of Hc-TeTx have been related to its ability to activate the pathways of the tropomyosin receptor kinase, which are crucial for survival process. Our group had previously shown neuroprotective effect of intramuscular Hc-TeTx treatment on animals with a dopaminergic lesion; however, there is no evidence indicating its restorative effects on advanced dopaminergic neurodegeneration. The aim of our study was to examine the restorative effects of an intramuscular injection of the Hc-TeTx fragment on the nigrostriatal system of hemiparkinsonian rats. The animals were administered with a vehicle or Hc-TeTx (20μg/kg) in the gastrocnemius muscle for three consecutive days post-dopaminergic lesion, which was made using 6-hydroxydopamine. Post-Hc-TeTx treatment, the hemiparkinsonian rats showed constant motor asymmetry. Moreover, the ipsilateral striatum of the post-Hc-TeTx group had a lower number of argyrophilic structures and a major immunorreactivity to Tyrosine Hydroxylase in the striatum and the substantia nigra pars compacta compared to the 6-OHDA group. Our results show the restorative effect of the Hc-TeTx fragment during the dopaminergic neurodegeneration caused by 6-OHDA.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>Mexique</li><li>États-Unis</li></country><region><li>Catalogne</li><li>Pennsylvanie</li></region><settlement><li>Barcelone</li></settlement><orgName><li>Université autonome de Barcelone</li></orgName></list><tree><country name="Mexique"><noRegion><name sortKey="Sanchez Gonzalez, Alejandra" sort="Sanchez Gonzalez, Alejandra" uniqKey="Sanchez Gonzalez A" first="Alejandra" last="Sánchez-González">Alejandra Sánchez-González</name></noRegion><name sortKey="Lim N, Ilhuicamina Daniel" sort="Lim N, Ilhuicamina Daniel" uniqKey="Lim N I" first="Ilhuicamina Daniel" last="Lim N">Ilhuicamina Daniel Lim N</name><name sortKey="Luna, Felix" sort="Luna, Felix" uniqKey="Luna F" first="Félix" last="Luna">Félix Luna</name><name sortKey="Palafox, Victoria" sort="Palafox, Victoria" uniqKey="Palafox V" first="Victoria" last="Palafox">Victoria Palafox</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Mendieta, Liliana" sort="Mendieta, Liliana" uniqKey="Mendieta L" first="Liliana" last="Mendieta">Liliana Mendieta</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Candalija, Anna" sort="Candalija, Anna" uniqKey="Candalija A" first="Anna" last="Candalija">Anna Candalija</name></region><name sortKey="Aguilera, Jose" sort="Aguilera, Jose" uniqKey="Aguilera J" first="José" last="Aguilera">José Aguilera</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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